Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges
Abstract Signal transducers and activators of transcription 3 (STAT-3) is a transcription factor that regulates the gene expression of several read more target genes.These factors are activated by the binding of cytokines and growth factors with STAT-3 specific receptors on cell membrane.Few years ago, STAT-3 was considered an acute phase response