Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges

Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges

Blog Article

Abstract Signal transducers and activators of transcription 3 (STAT-3) is a transcription factor that regulates the gene expression of several read more target genes.These factors are activated by the binding of cytokines and growth factors with STAT-3 specific receptors on cell membrane.Few years ago, STAT-3 was considered an acute phase response element having several cellular functions such as inflammation, cell survival, invasion, metastasis and proliferation, genetic alteration, and angiogenesis.STAT-3 is activated by several types of inflammatory cytokines, carcinogens, viruses, growth factors, and oncogenes.Thus, the STAT3 pathway is a potential target for cancer therapeutics.

Abnormal STAT-3 activity in tumor development and cellular transformation can be targeted by several genomic and pharmacological methodologies.An extensive review of the literature has been conducted to emphasize the role of STAT-3 as a unique cancer drug target.This review article discusses miracle academy clothing in detail the wide range of STAT-3 inhibitors that show antitumor effects both in vitro and in vivo.Thus, targeting constitutive STAT-3 signaling is a remarkable therapeutic methodology for tumor progression.Finally, current limitations, trials and future perspectives of STAT-3 inhibitors are also critically discussed.